Hello! It is still National Kidney Month, and I meant to talk about this topic weeks ago, but I got busy with other things and it didn’t happen.
I am not going to go into all the mumbo jumbo of a clinical trial, there is a video for that, lol. The video below will talk about the clinical trials for Farxiga and the results. I will keep it simple and state it met all of their standards with flying colors! The FDA has now approved Farxiga for the treatment and prevention of kidney decline in CKD patients with or without Diabetes. This is huge!
Now, before you get too excited there are some caveats. It is for stages CKD 2-4, and you can not be on hemodialysis. You can read the drug information here, but if you are on a low sodium diet, and which person with CKD is not on a low sodium diet, then you need to proceed with caution as Farxiga can cause you to be dehydrated, and cause volume loss. Make sure you discuss all aspects of this drug if you decide to ask your doctor about using it. The people in the clinical trials were on ACE Inhibitors, or ARBS, most likely to control blood pressure. So, I would be curious to know how Farxiga would work for those of us who do not take those medications. Not all of us do, though it is a typical standard of care for most people with CKD. Also, and most important in my mind, is that Farxiga can cause a type of genital infection, that can lead to gangrene, in the genitals. Yes, you read that correctly. You would need to pay extra attention to this very sensitive part of your body for any signs of infection. You also can not have Polycystic Kidney Disease or autoimmune kidney disease to take Farxiga. There are other drugs in this class of medication, but only Farxiga has been FDA approved for the treatment of CKD. Farxiga is made by Astrazeneca.
Now, my thoughts on Farxiga. Would I take it to slow the progression of my CKD? Absolutely, if what I was currently doing did not already have me back hovering at stage 2. I also do not take Ace inhibitors or ARBS, so I probably would be disqualified from using it. I do not want to be on hemodialysis, ever, and so this would be something I would consider. I would request my doctor make adjustments in my plan of care, such as sodium restrictions, and I would request closer monitoring for side effects.
Be sure and watch the videos, read the links, and educate yourself before talking to your doctor about taking Farxiga.